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Manual differential liquid handling

Differential Pipettors

Precision low-volume aspiration with the option of clean, contact-free delivery. Discover DRD’s dual-piston manual pipettor and the NEPTUNE96 semi-automated platform.

DRD differential pipettor
Differential displacement

Fine aspiration. Powerful delivery.

Differential Pipettors use two closely sized pistons to achieve fine net liquid displacement without relying on a fragile, very narrow piston.

Robust dual-piston design

Sturdy pistons and compliant seals support low-volume precision.

Contact-free dispensing

Deliver by blowoff without touching the receiving site; conventional touch-off is also possible.

Low-volume capability

DRD describes models capable of aspirating down to 0.2 µL.

DRD manual differential pipettors

The hand-held Differential Pipettor

The visible piston design makes it possible to see the paired mechanism while working. Options include adjustable and fixed-volume models.

Download current pipettor brochure ↗
96-channel semi-automated pipetting

Meet NEPTUNE96

A semi-automated desktop platform combining electronically controlled aspiration and dispense behavior with manually guided head and carriage motion.

NEPTUNE96 pipetting system

96 channels. 384-well access.

DRD describes contact-free dispensing down to 200 nL, with a quadrant locator for 384-well plates. The control software manages piston operation while the user positions the system.

Differential Pipettor demonstration

Rapid low-volume pipetting

NEPTUNE96 overview

NEPTUNE96 mechanism

Explore the technology

Talk to DRD about your workflow

Review manual pipetting requirements, volume ranges, tip choices, and NEPTUNE96 demonstrations.

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Frequently asked questions

How does a Differential Pipettor work?

Two pistons of slightly different effective areas move together to generate a fine net volume displacement.

Can the hand-held pipettor dispense without touching the receiving surface?

Yes. DRD describes a blowoff mode for contact-free delivery, alongside conventional touch-off techniques.

What is NEPTUNE96?

A semi-automated 96-channel differential pipetting platform combining controlled aspiration and dispensing with operator-guided movement.

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Explore the science behind this product

Read DRD’s technical guides for context on liquid-handling mechanisms, applications and validation.

Browse all technical articles →