Patented dual-piston Differential Displacement Pipettors are designed to aspirate samples down to nanoliter volumes and deliver even the smallest samples contact-free.
The problem below 10 µL
Manual and automated pipetting at small volumes can be affected by unstable aspiration, hanging drops, and delivery techniques that require contact with the receiving surface. These effects introduce operator- and geometry-dependent variability into a foundational laboratory operation.
Two pistons, two useful behaviors
Two tightly sealed pistons of slightly different diameters move together in one chamber. Their cross-sectional difference creates a small net displacement for fine aspiration resolution. Operating one piston alone creates the higher flow needed to propel a small sample cleanly from the tip to its destination.
Reported performance
The abstract reports a 0.1–20 µL working range for the handheld configuration, a 1 µL coefficient of variation of 2%, accuracy of 3–4%, and a standard deviation near 0.02 µL across the stated range.
This page summarizes DRD’s submitted SLAS abstract. Performance depends on configuration and study conditions; application-specific validation is recommended.
